Figure 1 Significant effects of ovariectomy (OVX), estradiol (OVX+E2), and soy isoflavones (OVX+SIF) on serum estradiol level. The data are presented as the mean±SD, n=6. aSignificant difference versus the sham (SH) group; bsignificant difference versus the ovariectomized (OVX) group; csignificant difference versus estradiol treatment. *P value less than 0.05, **P value less than 0.01, and***P value less than 0.001. Analysis of variance followed by Tukey’s correction for multiple comparisons.