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  Indian J Med Microbiol
 

Figure 1 The graph showed the results of the pain test. (a) The latency of pain in animals during hot plate test set at 55°C. The ligated animals (LIG, LIG+GABA) had a low threshold of pain as seen from the graph with a significant decrease (P<0.05) in the latency of time. Animals treated with GABA agonist after ligation (LIG+GABA) did not show improvement in their threshold of pains compared with the SHAM and no significant difference was observed in the pain threshold of ligated and GABA-treated ligated animals. (b) The pain perception results from formalin test (acute and chronic phase). At acute phase animals treated with GABA agonist (LIG+GABA) showed the highest number of paw flinches which was significantly higher (P<0.05) compared with the sham and ligated animals only (SHAM, LIG). No significant difference was observed when SHAM and LIG were compared. Ligated animals and those treated with GABA agonist (LIG, LIG+GABA) have increased the number of flinches, which are significantly higher (P<0.01) compared with sham animals. A significant difference was not observed when LIG and LIG+GABA when compared in the chronic phase.

Figure 1 The graph showed the results of the pain test. (a) The latency of pain in animals during hot plate test set at 55°C. The ligated animals (LIG, LIG+GABA) had a low threshold of pain as seen from the graph with a significant decrease (<i>P</i><0.05) in the latency of time. Animals treated with GABA agonist after ligation (LIG+GABA) did not show improvement in their threshold of pains compared with the SHAM and no significant difference was observed in the pain threshold of ligated and GABA-treated ligated animals. (b) The pain perception results from formalin test (acute and chronic phase). At acute phase animals treated with GABA agonist (LIG+GABA) showed the highest number of paw flinches which was significantly higher (<i>P</i><0.05) compared with the sham and ligated animals only (SHAM, LIG). No significant difference was observed when SHAM and LIG were compared. Ligated animals and those treated with GABA agonist (LIG, LIG+GABA) have increased the number of flinches, which are significantly higher (<i>P</i><0.01) compared with sham animals. A significant difference was not observed when LIG and LIG+GABA when compared in the chronic phase.