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  Indian J Med Microbiol
 

Figure 2: Hematoxylin and eosin (H&E)-stained liver sections (×200, ×400). (a1, a2) Control group with a normal structure and architecture; (b1 and b2) low-dose (LD) copper oxide nanoparticles (CuO-NPs)-intoxicated rats showing preserved lobular hepatic architecture, hepatocyte with ballooning (black arrow), binucleated hepatocytes (yellow arrow), microsteatotic changes (red arrow), and central vein congestion (green arrow); (c1 and c2) high-dose (HD) CuO-NPs-intoxicated rats showing preserved lobular hepatic architecture, hepatocyte with ballooning (black arrow), binucleated hepatocytes (yellow arrow), sinusoidal dilatation (red arrow), and lymphocytes aggregates (green arrow); (d1 and d2) LD CuO-NPs+quercetin (que) rats showing hepatic tissue with normal architecture, congestion, and dilatation of the sinusoids (black arrow); (e1 and e2) HD CuO-NPs+que group showing hepatic tissue with mild hydropic degeneration (black arrow), intracytoplasmic vacuoles (green arrow), congestion, and dilatation of the sinusoids (red arrow) and intralobular lymphocytic collection (yellow arrow); (f1 and f2) LD CuO-NPs+silymarin rats showing hepatic tissue with moderate ballooning of the hepatocytes and intracytoplasmic vacuoles (black arrow), congestion, and dilatation of the central vein (red arrow) and binucleated hepatocytes (yellow arrow); (g1 and g2) CuO-NPs+silymarin rats showing hepatic tissue with mild hydropic degeneration (black arrow) and intralobular lymphocytic collection (yellow arrow)

Figure 2: Hematoxylin and eosin (H&E)-stained liver sections (×200, ×400). (a<sub>1</sub>, a<sub>2</sub>) Control group with a normal structure and architecture; (b<sub>1</sub> and b<sub>2</sub>) low-dose (LD) copper oxide nanoparticles (CuO-NPs)-intoxicated rats showing preserved lobular hepatic architecture, hepatocyte with ballooning (black arrow), binucleated hepatocytes (yellow arrow), microsteatotic changes (red arrow), and central vein congestion (green arrow); (c<sub>1</sub> and c<sub>2</sub>) high-dose (HD) CuO-NPs-intoxicated rats showing preserved lobular hepatic architecture, hepatocyte with ballooning (black arrow), binucleated hepatocytes (yellow arrow), sinusoidal dilatation (red arrow), and lymphocytes aggregates (green arrow); (d<sub>1</sub> and d<sub>2</sub>) LD CuO-NPs+quercetin (que) rats showing hepatic tissue with normal architecture, congestion, and dilatation of the sinusoids (black arrow); (e<sub>1</sub> and e<sub>2</sub>) HD CuO-NPs+que group showing hepatic tissue with mild hydropic degeneration (black arrow), intracytoplasmic vacuoles (green arrow), congestion, and dilatation of the sinusoids (red arrow) and intralobular lymphocytic collection (yellow arrow); (f<sub>1</sub> and f<sub>2</sub>) LD CuO-NPs+silymarin rats showing hepatic tissue with moderate ballooning of the hepatocytes and intracytoplasmic vacuoles (black arrow), congestion, and dilatation of the central vein (red arrow) and binucleated hepatocytes (yellow arrow); (g<sub>1</sub> and g<sub>2</sub>) CuO-NPs+silymarin rats showing hepatic tissue with mild hydropic degeneration (black arrow) and intralobular lymphocytic collection (yellow arrow)