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  Indian J Med Microbiol
 

Figure 1 Ligand-based design of the target candidates 4a–f. Scheme 1 1Schematic diagram for the synthesis of compounds 4a–f. Reagents and conditions: (i): KSCN/Br2/AcOH, room temperature, 2–4 h; (b): ClCH2COCl/anhyd.K2CO3/benzene, reflux, 6–12 h; (c): 4-ethyl or 4-benzyl piperazine hydrochloride/anhyd. K2CO3/acetone, reflux, 6–12 h (Method 1) or benzyl piperazine hydrochloride/TEA/DMF, reflux 6 h, then H2O, room temperature,12 h (Method 2).

Figure 1 Ligand-based design of the target candidates 4a–f. Scheme 1 1Schematic diagram for the synthesis of compounds 4a–f. Reagents and conditions: (i): KSCN/Br<sub>2</sub>/AcOH, room temperature, 2–4 h; (b): ClCH<sub>2</sub>COCl/anhyd.K<sub>2</sub>CO<sub>3</sub>/benzene, reflux, 6–12 h; (c): 4-ethyl or 4-benzyl piperazine hydrochloride/anhyd. K<sub>2</sub>CO<sub>3</sub>/acetone, reflux, 6–12 h (Method 1) or benzyl piperazine hydrochloride/TEA/DMF, reflux 6 h, then H<sub>2</sub>O, room temperature,12 h (Method 2).