Year : 2015 | Volume
: 14 | Issue : 3 | Page : 166--173
Nanoemulsions as parenteral drug delivery systems for a new anticancer benzimidazole derivative: formulation and in-vitro evaluation
Rawia M Khalil, Mona Basha, Rabab Kamel
Department of Pharmaceutical Technology, National Research Center, Cairo, Egypt
Recently, much attention has been paid to the application of nanoemulsions (NEs) as drug delivery systems. Besides their high solubilization capacity, NEs are powerful carrier systems because of their thermodynamic stability, ease of preparation, and high absorption rates.
The present work focuses on the design of stable and dilutable NEs for intravenous administration of a potent antitumor benzimidazole derivative, a poorly water-soluble active ingredient.
Materials and methods
NEs were formulated using ethanol as cosurfactant and Tween 20, Acconon MCF, and Labrasol as surfactants using the oil with maximum drug solubilization. Selected NEs were evaluated for droplet size, zeta potential, morphology, in-vitro release profile, and physical stability.
The results revealed the development of eight NEs composed of 10% oleic acid with an infinite dilution capacity. NE3, NE6, and NE8 having the highest surfactant to cosurfactant ratio (3: 1) showed the best drug solubilization capacity. The NE droplets appeared almost spherical, ranging from 28.21 to 153.00 nm, with narrow distribution and relatively high zeta potential. NEs demonstrated sustained release profiles, whereas increasing surfactant to cosurfactant ratio was accompanied by increased drug release. NEs showed excellent physical stability with no phase separation or change in particle size.
Our results suggest that NEs can be used as a promising intravenous delivery system.
PhD, Pharmaceutical Technology Department, National Research Center, El-Bohooth Street, 12311 Cairo
|How to cite this article:|
Khalil RM, Basha M, Kamel R. Nanoemulsions as parenteral drug delivery systems for a new anticancer benzimidazole derivative: formulation and in-vitro evaluation.Egypt Pharmaceut J 2015;14:166-173
|How to cite this URL:|
Khalil RM, Basha M, Kamel R. Nanoemulsions as parenteral drug delivery systems for a new anticancer benzimidazole derivative: formulation and in-vitro evaluation. Egypt Pharmaceut J [serial online] 2015 [cited 2021 Oct 18 ];14:166-173
Available from: http://www.epj.eg.net/article.asp?issn=1687-4315;year=2015;volume=14;issue=3;spage=166;epage=173;aulast=Khalil;type=0