Egyptian Pharmaceutical Journal

REVIEW ARTICLE
Year
: 2013  |  Volume : 12  |  Issue : 1  |  Page : 1--10

D2M-dopaminergic receptor and 5-HT3 serotoninergic receptor antagonists having antiemetic profile


Mohamed N. Aboul-Enein1, Aida A. EL-Azzouny1, Yousreya A. Maklad1, Mohamed I. Attia2, Mohamed Abd EL-Hamid Ismail3, Walaa H.A. Abd EL-Hamid4 
1 Department of Medicinal and Pharmaceutical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, Egypt
2 Department of Medicinal and Pharmaceutical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, Egypt; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Misr University for Science &Technology, 6th of October City, Egypt

Correspondence Address:
Mohamed N. Aboul-Enein
Department of Medicinal and Pharmaceutical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, 12622 Dokki, Giza, Egypt

Metoclopramide is the prototype of the orthopramide family and is used clinically as a stimulant of upper gastrointestinal motility and as an antiemetic. Its antiemetic potential is attributed mainly to the antagonist activity at D2-dopaminergic receptors in the chemoreceptor trigger zone of the central nervous system. Besides, ondansetron was the first selective 5-HT3 serotoninergic receptor antagonist used in clinics as an antiemetic. Herein, the antiemetic profile of different chemical classes of D2-dopaminergic receptor and 5-HT3 serotoninergic receptor antagonists will be discussed, which may be helpful in the development of potent antiemetic agents.




How to cite this article:
Aboul-Enein MN, EL-Azzouny AA, Maklad YA, Attia MI, Abd EL-Hamid Ismail M, Abd EL-Hamid WH. D2M-dopaminergic receptor and 5-HT3 serotoninergic receptor antagonists having antiemetic profile.Egypt Pharmaceut J 2013;12:1-10


How to cite this URL:
Aboul-Enein MN, EL-Azzouny AA, Maklad YA, Attia MI, Abd EL-Hamid Ismail M, Abd EL-Hamid WH. D2M-dopaminergic receptor and 5-HT3 serotoninergic receptor antagonists having antiemetic profile. Egypt Pharmaceut J [serial online] 2013 [cited 2021 Aug 4 ];12:1-10
Available from: http://www.epj.eg.net/article.asp?issn=1687-4315;year=2013;volume=12;issue=1;spage=1;epage=10;aulast=Aboul-Enein;type=0