Year : 2021  |  Volume : 20  |  Issue : 4  |  Page : 339-351

Protective efficiency of Eclipta prostrata on diet-induced nonalcoholic fatty liver disease in rats using the urinary lipidomics approach

1 Department of Therapeutic Chemistry, National Research Centre, Cairo, Egypt
2 Department of Biochemistry, Ain Shams University, Cairo, Egypt
3 Department of Biochemistry, National Research Centre, Cairo, Egypt
4 Department of Medicinal and Aromatic Plants, National Research Centre, Cairo, Egypt
5 Department of Applied Biochemistry, National Research Centre, Cairo, Egypt

Correspondence Address:
PhD Noha S Hussein
Department of Therapeutic Chemistry, National Research Centre, Cairo, 12622
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/epj.epj_40_21

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Background Nonalcoholic fatty liver disease (NAFLD) is currently one of the leading causes of chronic liver disease in western countries and is characterized by excessive fat deposition in the liver. It affects 15–30% of the general population worldwide. Objectives This study aims to detect and evaluate a reproducible signature of lipid metabolome for early detection of NAFLD as well as protective efficiency of Eclipta prostrata based on targeted metabolomics analysis of urine. Results and conclusion A discrete divergence in levels of glycerol, myristic acid, cholesterol, 1,3-dipalmitin, and oleic acid was recorded in urine of rats bearing NAFLD in contrast to healthy ones. These metabolites were considered as diagnostic metabolic biomarkers for NAFLD. This study showed that these metabolites were less affected in rats given E. prostrata as a protective agent. It is concluded from this research that the lipidomic approach could be used for early diagnosis of NAFLD in urine as well as assessment of the stratification of protection by herbal medication.

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