REVIEW ARTICLE
Year : 2021  |  Volume : 20  |  Issue : 4  |  Page : 264-269

Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer


1 Holding Company for Biological Products and Vaccines (VACSERA-Egypt), Giza, Egypt
2 Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt

Correspondence Address:
PhD Ghada M El-Feki
Egyptian Organization for Biological Products and Vaccines (VACSERA Holding Company), 51 Wezaret El-Zeraa Street, Agouza, Giza, 12654
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/epj.epj_50_21

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Background Tryptase and chymase are potent proteases secreted by mast cells upon activation. These abundant mast-cell proteases are converted into catalytically active forms by dipeptidyl peptidase 1 (DPP1). DPP1 is one of the most important components to initiate chain reaction for triggering the inflammatory response mediating allergic diseases such as asthma and allergic rhinitis. DPP1 can remove the safety catch on various mast-cell proteases, including tryptase and chymase, and plays an essential role in controlling their activity. However, the exact role of DPP1 in mast-cell degranulation is still not fully recognized. DPP1 may help mast cells degranulate via acting inside the cell or after secretion. DPP1 inhibitors are essential for mast-cell stabilization. In this review, we will discuss the contribution of DPP1 in mast-cell degranulation and the role of DPP1 inhibitors in mast-cell stabilization, which may help finding new therapeutic strategies for asthma.


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