Year : 2021  |  Volume : 20  |  Issue : 2  |  Page : 105-114

Oral disintegrating tablets: best approach for faster therapeutic action of poorly soluble drugs

1 Balaji Institute of Pharmaceutical Sciences, Narsampet, Warangal, Telangana, India
2 Department of Pharmaceutics, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, India

Correspondence Address:
PhD Santosh K Rada
GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam 530045, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/epj.epj_63_20

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Drug carrier networks are sophisticated because pharmaceutical scientists gain a greater understanding of the performance of biochemical as well as physicochemical parameters. Oral disintegrating tablets (ODTs) are now more commonly available for the treatment of various diseases than other products. Due to its convenience in terms of manufacture and administration, the oral administration route is being studied as the most utilized route. ODTs, particularly for pediatric patients, are considered to be effective drug-delivery systems due to their quick disintegration properties, water-free usage, and ease of swallowing. ‘Orally disintegrating tablets’ are present in solid dosage forms that dissolve in the mouth in less than 60 s without the need for water. Rapid tablet disintegration leads to rapid dissolution and therefore rapid action. ODTs are an ideal treatment for specific populations such as unconscious patients, bedridden patients, dysphagic patients, psychotic patients, geriatric patients, pediatric patients, and young patients with underdeveloped nervous and muscular systems. The main aim of this research paper is to discuss the advantages, drawbacks, formulation problems, manufacturing methods, patented technology, evaluation tests, and marketed formulations of ODTs, their value, different technologies, ideal characteristics, and aspects of formulation and design, future perspectives, and marketed preparations, particularly for pediatric patients.

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