ORIGINAL ARTICLE
Year : 2020  |  Volume : 19  |  Issue : 4  |  Page : 350-360

Effect of sage oil on tamoxifen-induced hepatotoxicity and nephrotoxicity in female rats


1 Department of Medical Physiology, National Research Centre, Giza, Egypt
2 Department of Pathology, National Research Centre, Giza, Egypt

Correspondence Address:
PhD Hagar H Mourad
Department of Medical Physiology, National Research Centre, Giza, 12622
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/epj.epj_32_20

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Background and objective Sage oil has anti-inflammatory and antioxidant activities. The current study was designed to evaluate the efficacy of sage oil at two different doses against hepatotoxicity and nephrotoxicity induced by tamoxifen in female rats. Materials and methods A total of 56 female Wistar albino rats were divided into control, sage control, tamoxifen-treated rats (45 mg/kg body weight), and rats treated with tamoxifen along with sage oil (0.2 ml/kg or 0.4 ml/kg). Each dose of sage oil was used as a protective (before tamoxifen) and as a therapeutic (after tamoxifen) treatment. At the end of the experiment, serum levels of tumor necrosis factor-alpha, as well as liver and kidney function biomarkers, were measured. Levels of lipid peroxidation (malondialdehyde), nitric oxide, and reduced glutathione and the activities of glutathione peroxidase and Na+/K+-ATPase were measured in liver and kidney homogenates. Sections of liver and kidney were examined for histopathological changes. Results and conclusion Tamoxifen-induced hepatic and renal impairment was evident from the significant elevation in alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase activities and bilirubin, urea, and creatinine levels. Furthermore, tamoxifen significantly increased serum tumor necrosis factor-alpha, as well as hepatic and renal malondialdehyde and nitric oxide levels. This was accompanied by a significant decrease in the levels of glutathione and the activities of glutathione peroxidase and Na+/K+-ATPase in liver and kidney. Treatment with sage oil at high dose (0.4 ml/kg) ameliorated almost all the biochemical and histopathological changes induced by tamoxifen in liver and kidney. In conclusion, sage oil has the ability to attenuate hepatotoxicity and nephrotoxicity induced by tamoxifen.


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