Year : 2018  |  Volume : 17  |  Issue : 1  |  Page : 53-59

Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines

1 Department of Pharmacy, Vaageswari College of Pharmacy, Telangana, India
2 Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, India

Correspondence Address:
Kola Venu
Vaageswari College of Pharmacy, Karimnagar, Telangana 505481
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/epj.epj_1_18

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Context Ketorolac (KT) is a NSAID, with multiple pharmacological activities having been reported. Aim To formulate chitosan nanoparticles of KT for assessing their potential in decreasing the growth of colon cancer cells. Materials and methods Chitosan nanoparticles of KT such as F1 and F2 have shown anticancer activity against SCC-29 cell lines. Furthermore, nanoparticles have been subjected to stability test at various pH, drug-release study, and in-vivo pharmacokinetics in Wistar rats. Results The nanoparticles were in the size range between 164 and 210 nm. The oral absorption of nanoparticles was relatively higher than the KT alone. Conclusion The prepared nanoparticle formulations showed better activity than KT alone.

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