Year : 2017  |  Volume : 16  |  Issue : 1  |  Page : 62-68

Development and evaluation of nanosized aripiprazole-loaded bioflexy films using a biopolymer from Lagenaria siceraria for brain delivery through orosoft palatal mucosal platform

Drug Delivery Research Laboratory, Faculty of Pharmacy, DIT University, Dehradun, India

Correspondence Address:
N V Satheesh Madhav
Drug Delivery Research Laboratory, Faculty of Pharmacy, DIT University, Makkawala, P.O. Bhagwantpur, Dehradun 248009, Uttarakhand
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1687-4315.205832

Rights and Permissions

Purpose The National Institute of Mental Health estimated the global cost of mental illness to be $6T by 2030. The purpose of the study was to deliver aripiprazole for brain targeting by suitably designing a bioflexy film for the treatment of different brain disorders. Materials and methods Bioflexy films were prepared by solvent casting technique using aripiprazole as a model drug, different concentrations of isolated biopolymer from Lagenaria siceraria, and a standard polymer. Results All formulations of aripiprazole were flexible, smooth, and transparent in nature, with a weight range from 23.73 to 34.48 mg, pH range from 7.27 to 7.39, and folding endurance of 94–116 times. The content uniformity was in the range of 97.2–98.6. Conclusion In-vitro and in-vivo release shows FL2 as the best formulation. On the basis in-vitro and in-vivo drug release, FL2 was found to be best formulation showing mucoadhesivity (36 h), t50% of 2.5 h, t80% of 23.4 h, and having R2 value of 0.9923, best-fit model Higuchi matrix analyzed by BIT-SOFT 1.12. Moreover, it was observed that significant amount of drug reaches to the brain through soft palatal route through neural pathway.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded317    
    Comments [Add]    

Recommend this journal