Year : 2012  |  Volume : 11  |  Issue : 1  |  Page : 59-65

Bioactive lignans and other phenolics from the roots, leaves and seeds of Arctium lappa L. grown in Egypt

1 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt
2 Department of Pharmacognosy, National Organization for Drug Control and Research, Cairo, Egypt
3 Department of Pharmacology, National Research Center, Giza, Egypt

Correspondence Address:
Elsayed A. Aboutabl
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr-el-Aini Str., 11562 Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.7123/01.EPJ.0000415466.17860.6a

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Investigation of the phenolic constituents of roots, leaves and seeds of A. lappa L. cultivated in Egypt.


Qualitative and quantitative analysis of lignans and other phenolics by LC-MS/MS and HPLC/PDA-LC-MS/MS, as well as evaluation of potential bioactivities.

Results and conclusions

LC-MS/MS of the ethyl acetate fractions from Arctium lappa seeds, leaves and roots showed the presence of 13 phenolics, including lignans, distributed in the different organs. The following phenolics were identified: caffeic acid 1, genistein 2, biochanin A 3, luteolin 4, chlorogenic acid 5, materisenol 6, arctigenin 7, quercetin 8, cynarin 9, arctiin 10, lappaol A 11, rutin 12 and lappaol F 13. Quantification of these compounds by HPLC-PDA-MS/MS showed that arctiin was the major compound in seeds. The antioxidant, antihepatotoxic, anti-inflammatory and cytotoxic activities of ethanolic extracts of the different organs were evaluated.

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