Year : 2012  |  Volume : 11  |  Issue : 1  |  Page : 38-41

Inhibitory effect of some local medicinal plants on in-vitro oxidative modification of low-density lipoprotein

1 Department of Chemistry of Natural Products, National Research Center, Giza, Egypt
2 Department of Zoonosis, National Research Center, Giza, Egypt
3 Chemistry Department, Biochemistry Division, Faculty of Science, Helwan University, Cairo, Egypt

Correspondence Address:
Faten K. Abd El-Hady
Department of Chemistry of Natural Products, National Research Center, 12622 Giza
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.7123/01.EPJ.0000416047.70867.4c

Rights and Permissions


Oxidative modification of low-density lipoprotein (LDL) has been implicated in atherogenesis. Antioxidants that prevent LDL oxidation may reduce atherosclerosis.


The antioxidant activity of 45 extracts from 15 locally used medicinal plants were studied in-vitro employing using three different systems; the DPPH (1,1-diphenyle-2-picryl-hydrazyl) radical scavenging assay, superoxide anion generated in Xanthine–Xanthine oxidase (X-XOD) system and the LDL oxidation induced by cupper ions.


It was observed that the leaf extracts of olive, Jew's mallow, celery, the seed extract of celery and safflower, and ginger extracts had the highest antioxidant activity in the three assays.


It could be concluded that these plant extracts could play an important role in the inhibition of lipid peroxidation in biological systems through their antioxidant, metal chelating, and free radical scavenging activities.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded143    
    Comments [Add]    

Recommend this journal